Month: August 2020

Stem cell transplantation for CARD 11 loss of function

Reference: Al-Rasheed, B., Alazami, A.M. & Al-Mousa, H. Phenoidentical HLA-Related Hematopoietic Stem Cell Transplant Without Conditioning to Reconstitute a Patient with a Putative Loss-of-Function CARD11 Mutation. J Clin Immunol (2020). https://doi.org/10.1007/s10875-020-00846-y Journal: Journal of Clinical Immunology Take Home Message: Authors report a case of CARD 11 loss of function mutation who underwent unconditioned HSCT

Haploidentical Transplantation in XIAP

Reference: Yang, J., Zhu, G., Wang, B. et al. Haploidentical Hematopoietic Stem Cell Transplantation for XIAP Deficiency: a Single-Center Report. J Clin Immunol 40, 893–900 (2020). https://doi.org/10.1007/s10875-020-00795-6 Bottom line: More studies are needed to determine the suitability of modified MAC for haploidentical transplantation in XIAP

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